Transcriptional Control of Lineage Differentiation in Immune by Wilfried Ellmeier, Ichiro Taniuchi

By Wilfried Ellmeier, Ichiro Taniuchi

Insights into the legislation of immune mobilephone lineage differentiation and specification in addition to into the regulate of lineage integrity, balance and plasticity are of basic significance to realizing innate and adaptive immune responses. during this quantity, top specialists offer an up to date and complete review of contemporary advances within the transcriptional keep an eye on mechanisms and transcription issue networks that keep an eye on those strategies in numerous various immune mobile lineages. The chapters conceal the rules of T as opposed to B telephone lineage selection, speak about early B phone improvement and pre-B cellphone leukemia prevention, deal with transcriptional keep an eye on mechanisms in the course of the differentiation, in regulatory T cells and iNKT cells, aspect genomic switches in helper cellphone destiny selection and plasticity and spotlight the function of the BTB-zinc finger relatives of transcription elements in T cells. furthermore, the chapters talk about transcriptional networks in DCs, NK cells and in innate lymphoid cells. jointly, the studies illustrate key transcriptional keep watch over mechanisms that keep an eye on the advance and serve as of immune cells and exhibit the awesome advances remodeled the final decade.

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References Abramova A, Sakaguchi S, Schebesta A, Hassan H, Boucheron N, Valent P, Roers A, Ellmeier W (2013) The transcription factor MAZR preferentially acts as a transcriptional repressor in mast cells and plays a minor role in the regulation of effector functions in response to FcepsilonRI stimulation. PLoS ONE 8(10):e77677. 0077677 Adhikary S, Peukert K, Karsunky H, Beuger V, Lutz W, Elsasser HP, Moroy T, Eilers M (2003) Miz1 is required for early embryonic development during gastrulation.

Subsequent studies showed that Miz-1 is also essential for the T cell lineage. Loss of Miz-1 (using the Vav-Cre-deleter strain) led to a severe reduction ([100 fold) of thymocyte numbers accompanied also by a severe reduction of DN subsets, in particular ETP/ DN1 and DN2 stages (Saba et al. 2011b). By performing a comprehensive in vitro analysis using the OP9-DL1 system, the drop in ETP/DN1 cells could be linked to extensive cell death in the absence of Miz-1. A further analysis showed that Miz-1 regulates the expression of SOCS1, most likely by a direct regulation since Miz-1 binds to the Socs1 promoter region and loss of Miz-1 leads to an upregulation of Socs1 expression.

2013a). This indicates that loss of LRF/Zbtb7a indirectly affects B versus T cell choice. In the T cell lineage, LRF/Zbtb7a is expressed at low levels in DP thymocytes and is upregulated to much higher levels in CD4SP and CD8SP thymocytes and in peripheral T cells (Carpenter et al. 2012). However, deletion of LRF/Zbtb7a using The Role of BTB-Zinc Finger Transcription Factors 37 Cd4-Cre did not lead to any alterations during T cell development (Carpenter et al. 2012). A surprising role for LRF/Zbtb7a in the control of Th cell-specific gene expression was identified by Bosselut and colleagues when T-helper immune responses were analyzed in ThPOK-deficient mice (Carpenter et al.

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