Denson G. Fujikawa 2+ within the early Nineteen Eighties it was once famous that over the top Ca inflow, most likely via 2+ 2+ voltage-gated Ca channels, with a resultant bring up in intracellular Ca, was once linked to neuronal loss of life from cerebral ischemia, hypoglycemia, and standing epilepticus (Siejo 1981). Calcium activation of phospholipases, with arachidonic acid accumulation and its oxidation, producing loose radicals, was once considered a possible mechanism through which neuronal harm happens. In cerebral ischemia and a pair of+ hypoglycemia, strength failure used to be considered the cause of over the top Ca inflow, while in prestige epilepticus it used to be concept that repetitive depolarizations have been liable (Siejo 1981). in the meantime, John Olney came across that monosodium glutamate, the nutrients additive, while given to immature rats, was once linked to neuronal degeneration within the arcuate nucleus of the hypothalamus, which lacks a blood-brain barrier (Olney 1969). He up this statement with a sequence of observations within the Nineteen Seventies that management of kainic acid, which we now understand prompts the GluR5-7 subtypes of glutamate receptor, and different glutamate analogues, prompted not just post-synaptic cytoplasmic swelling, but additionally dark-cell degeneration of neurons, whilst seen through electron microscopy (Olney 1971; Olney et al. 1974).
Read Online or Download Acute Neuronal Injury: The Role of Excitotoxic Programmed Cell Death Mechanisms PDF
Similar neurology books
From the reviews:"The atlas is largely a compendium of the event and services of its writer over a hugely efficient expert lifetime. … The illustrations are all of excessive commonplace … . Neuropathologists and neurologists … will locate it necessary … to work out fantastically reproduced illustrations of unusual issues.
Here's the Fourth version of the vintage textual content Electrodiagnosis in illnesses of Nerve and Muscle: rules and perform. With every one next version, Dr. Kimura has equipped upon his vast adventure educating electromyography (EMG) worldwide and has transferred his wisdom to the ebook. it really is meant for clinicians who practice electrodiagnostic methods as an extension in their scientific exam, and may be of price to neurologists and physiatrists who're drawn to neuromuscular issues and noninvasive electrodiagnostic tools, really these working towards electromyography (EMG).
The 2 editors have succeeded in generating an exceptional reference on all elements of neurosurgical infections. it is a well-written, accomplished evaluation of a tough subject. -- Doody corporations, Inc. swift prognosis and remedy are an important to winning results in infections regarding the imperative worried procedure, which may reason major neurological morbidity and mortality.
Additional info for Acute Neuronal Injury: The Role of Excitotoxic Programmed Cell Death Mechanisms
Lavie P: The touch of Morpheus: Pre-20th century accounts of sleepy patients. 55. Guilleminault C: Disorders of excessive sleepiness. Ann Clin Res 1985;17:209-219. Guilleminault C: Idiopathic central nervous system hypersomnia. Neurol Clin 1996;14:513-543. Arch Gen Psychiatry 1988;45:267-273. Psychiatric Clin North Am 1987;10:565-581. Drug Saf 1997;16:133-149. Neurology 1991;41:1841-1844. In Kryger MH, Roth T, Dement WC (eds): Principles and practice of sleep medicine. B. Saunders, 1994, pp 562-566.
Schneck CH, Mahowald MW: REM sleep parasomnias. Neurol Clin 1996;14:697-720. Siegel JM: Brainstem mechanisms generating REM sleep. In Kryger MH, Roth T, Dement WC (eds): Principles and Practice of Sleep Medicine, 2nd ed. B. Saunders, 1994, pp 16-25. PreviousNext REFERENCES 1. Aserinsky E, Kleitman N: Regularly occurring periods of eye motility and concomitant phenomena during sleep. 2. Carskadon MA, Dement WC: Normal human sleep. 3. McCarley RW: Neurophysiology of sleep: Basic mechanisms underlying control of wakefulness and sleep.
Murphy PJ, Campbell SS: Physiology of the circadian system in animals and humans. 34. Brzezinski A: Melatonin in humans. 35. Jankel WR, Niedermeyer E: Sleep spindles. 36. Siegel JM: Brainstem mechanisms generating REM sleep. 37. Culebras A: Update on disorders of sleep and the sleep-wake cycle. Psychiatric Clin North Am 1992;15:467-489. 38. Jones BE: Paradoxical sleep and its chemical structural substrates in the brain. 39. Hobson JA, Lydic R, Baghdoyan HA: Evolving concepts of sleep cycle generation: From brain centers to neuronal populations.