By Pierre Hainaut, Klas G. Wiman
The invention of p53 in 1979 marks the start of a so much attention-grabbing period of contemporary melanoma study and molecular biology, an period that continues to be in complete swing and doesn't express any indicators of finishing within the foreseeable destiny. p53 has emerged as a key tumor suppressor and critical objective for novel melanoma remedy. For round 10 years, p53 was once thought of an oncogene with a bit of strange positive factors. even if, an enormous paradigm shift happened round 1988-89 while intriguing new findings confirmed that standard (wild variety) p53 may inhibit transformation of cells in tradition and that the p53 gene was once mutated in a wide fraction of human tumors. actually, p53 the main often mutated gene in melanoma cells. next paintings in the course of the 1990’s confirmed that p53 used to be a transcription issue that regulates many different genes, and that p53 can set off apoptosis, the suicide application of the telephone. This booklet, written through world-leading p53 researchers together with lots of those that have formed the sector over the last 25 years, presents distinctive insights into the development of the p53 box and the clients for larger melanoma analysis and treatment sooner or later. it's going to be of curiosity to everyone operating in melanoma examine, scientific oncology, and molecular biology, and certainly to anyone drawn to technology, medication, in addition to in contemporary advancements of the tips and ideas of the molecular biology of melanoma.
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Extra resources for 25 Years of P53 Research
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Nature, 1993. 366: 701-704. , Experimental study off the pathogenesis of carcinoma. Journal of Cancer Research, 1918. 3: 1-29. , Rannala B, Likelihood models of somatic mutation and codon substitution in cancer genes. Genetics, 2003. 165: 695-705. , Oren M. Sequence-specific DNA binding by p53: identification of target sites and lack k of binding to p53-MDM2 complexes. EMBO J, 1993. 12: 2799-2808. , Oren M. A functional p53-responsive intronic promoter is contained within the human mdm2 gene. , 1995.